Introduction: Water polo is a highly demanding activity that combines intensive work which is followed by periods of lower intensity. In addition to numerous changes in game rhythms, players have intensive periods of mutual contact. A high level of strength and anaerobic endurance is needed because of specific demands in water polo. Therefore, this research aimed to investigate the correlation between some anthropometric, general fitness, and sport-specific skills of female water polo players. Methods: The sample of participants included 11 female water polo players, all members of the Switzerland national team. The mean chronological age of participants is 27,11±3,98, all females. Variables included anthropometric/body-built indices (body mass, body height, body fat percentage, arm span). General fitness test variables included: Wingate arm crank test, countermovement jump, and Reactive strength index; sport-specific tests included: 25, 50, and 100-meter sprints. Correlations between the anthropometric and sport-specific tests were conducted along with the general and sport-specific tests. Results and Discussion: The results showed that body mass (0.91) and body fat (0.68) percentage are in positive correlation with Wingate arm crank test outputs. Also, body mass has a positive relation with reactive strength index (0.71), other variables did not perceive relations. Furthermore, analyzed sport-specific and general fitness tests, showed positive relations only between the reactive strength index and Wingate outputs (Peak power 0.86; average power 0.72; power drop 0.68). Correlations between sport-specific tests and outputs were not found. Conclusion: These results could imply that the Wingate arm crank test is not a good indicator of success in sport-specific tests. Also, 25, 50, and 100-meter sprints were not done in water polo swimming style, which could have affected on the performance athletes. Moreover, future research should include a bigger sample of participants and a more detailed sport-specific assessment.